Bionic Neurons that mimic how nerve cells convey electrical signals

A new bionic neuron chip tiny enough to fit on the tip of a finger has been designed by scientists to help the patient’s overcome paralysis and chronic diseases.

These bionic neurons have been developed to mimic cells in our nervous system. It receives electrical signals from healthy nerve cells, then sending them on to neurons in other muscles and organs in the body.

The long term objective is to use the device as a medical implant to treat conditions such as cardiac arrests and Alzheimer’s as it requires such litter power.

This small artificial neuron chip is less than 1.27 cm ( half an inch) across and only uses about one-billionth of the power required for a microprocessor such as the one used in a computer or mobile phone.

A neuron is a type of cell that carries electrical impulses around the nervous system sending information or relay signals from one part of the body to another.

Researchers say other possible applications could be in the treatment of conditions like Dementia and neuronal degenerative diseases more generally.

Scientists have created physical models of the hardware and demonstrated its ability to successfully mimic the behavior of real living neurons. They are hoping to be able to replicate all of the different nerve cells in the brain and neurons system. The objective is to use biotech implants to help people with long term illnesses by replacing functions failing due to disease.

Researchers are building artificial neurons out of silicon; they behave identically to biological neurons.

More specifically, they have constructed silicon models fo hypo compiled neurons and respiratory neurons in their inner cortex. Biological neurons typically have a weary complicated electrical behavior; it’s challenging to measure the flow of ion channels inside these neurons.

The scientific consortium developed techniques transfer the behavior of particle neurons into a piece of silicon such as this one.

Why is this important, well it because, as we know, neurons are part of the brain cortex central neurons system.

Diseases neurons they will decay, losing their functionality or dying altogether, neurons cannot regenerate, so it is essential to have bio circuits that eventually substitute these failing neurons to restore the vital function in diseases such as Dementia diseases.

So basically researchers, have been able to do these things by developing a mathematical technique, computational techniques, and also in the design of the normal chips.

Abstract

Optimal solid-state neurons

Bio-electronic medicine drives neuromorphic microcircuits that integrate raw nervous stimuli that respond identically to biological neurons. However, designing such circuits remains a challenge. Here we estimate the parameters of highly nonlinear conductance models and derive the ab initio equations of intracellular currents and membrane voltages embodied in analog solid-state electronics.

By configuring individual ion channels of solid-state neurons with parameters estimated from large-scale assimilation of electrophysiological recordings, we successfully transfer the complete dynamics of hippocampal and respiratory neurons in silico.

The solid-state neurons respond nearly identically to biological neurons under stimulation by a wide range of current injection protocols. The optimization of nonlinear models demonstrates a powerful method for programming analog electronic circuits.

This approach offers a route for repairing diseased bio circuits and emulating their function with biomedical implants that can adapt to biofeedback.

Noteworthy

This work opens new horizons for respiratory neuromorphic chip design thanks to its unique approach to identifying crucial analog circuit parameters.

Now that respiratory neurons can be replicated in bioelectronics in miniaturized implants.

It opens up enormous opportunities for smarter medical devices that drive towards personalized medicine approaches to a range of diseases and disabilities.
Replicate the brain memories with all it is different nerve cells and nervous systems; miniatures of new biotech implants are critical.

So they can be inserted into a patient’s brain posterior cerebral artery, which feeds the brain hippocampus, which manages short-term memories.

Achieve this; the new innovative implant must be tiny, with bionic neurons, the size, and the diameter of a human hair.

If we can achieve this, then the new biotech implant can help people with long term illnesses by replacing failed function due to disease.

Acknowledgments & References

Paul Lombroso, Professor, Yale University School of Medicine. Professor Giacomo Indiveri, a co-author of the study, from the University of Zurich and ETF Zurich, Another co-author, Professor Julian Paton, a physiologist at the University of Auckland and the University of Bristol Professor Alain Nogaret and Research Associate Kamal Abu Hassan in the lab at the University of Bath. Credit: University of Bath

 

 

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